Are you using the Web GUI to do the work?
There should be no problem in moving from DHCP assigned information to static config, but you must bear in mind that you will need to define everything. Specifically you need to add a gateway in Core>Network>Gateways, and make sure that the DNS is working as well.
Avoid messing with the configuration files directly, as they are recreated whenever a service is restarted and you will loose all your work.
If you need very specific configurations, you may want to read a little bit more about Zentyal and how to tune your system. It involves messing with the Mason templates system and/or hooks.