I'm using Zentyal 4.2.2 (started with 3.5) as multi domain email server. No AD integration, only email server placed in DMZ (Endian UTM).
Our clients are using MS Outlook 2010, 2013, Mozilla Thunderbird, as email desktop clients.
Some clients are using IMAP, but most of them, POP3.
Never had issues with the downloading of the attachments (except the cases that I have mentioned), send and receive, scheduled s&r, ...
Personal, I have installed both MS Outlook 2013 and Mozilla Thunderbird (for tests, to see how it works; some accounts use IMAP, some POP3).